Answered

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A patient presents to the emergency department with aspirin overdose. The new prescriber reads that aspirin is renally eliminated and wants to expedite the process. Based on your knowledge of pH partitioning and pharmacokinetics , what would you suggest to increase excretion of aspirin through the urine?
Group of answer choices
A. The patient should be administered ascorbic acid to make the urine more acidic. This will decrease ionization of aspirin and keep it trapped in the urine for elimination
B. The patient should be administered ascorbic acid to make the urine more acidic. This will increase ionization of aspirin and keep it trapped in the urine for elimination
C. The patient should be administered Sodium bicarbonate to make the urine more alkaline. This will decrease ionization of aspirin and keep it trapped in the urine for elimination
D. The patient should be administered Sodium bicarbonate to make the urine more alkaline. This will increase ionization of aspirin and keep it trapped in the urine for elimination

Sagot :

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