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A patient with a history of long-term immobilization due to a spinal injury is evaluated. Which cellular change is most likely observed in the patient’s unused leg muscles?

A. A decrease in the size of cells due to decreased workload
B. Accumulation of excess amounts of collagen and other extracellular matrix components
C. An increase in the number of cells in response to decreased neural stimulation
D. An increase in the size of cells without an increase in their number