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How does niacin work to lower cholesterol?

A. It reduces the blood fats called "very low-density lipoproteins," which have been linked to heart disease.
B. The flushing helps to rid the body of cholesterol.
C. It increases stomach acids to eliminate excess fats in the diet.
D. It increases urine output to eliminate excess fats in the diet.

Sagot :

Final answer:

Niacin, also known as vitamin B3, lowers cholesterol by limiting substrate for synthesis, increasing LDL receptor uptake, and reducing 'very low density lipoproteins'.


Explanation:

Niacin, also known as vitamin B3, works to lower cholesterol through several mechanisms:

  1. Reduction of mevalonate production: Limits substrate available for cholesterol synthesis.
  2. Increase in LDL receptors: Promotes uptake and destruction of LDLs, lowering serum cholesterol.
  3. Reduction of 'very low density lipoproteins': Linked to heart disease and reduced by niacin.

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