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Final answer:
Matthias Grünewald's Isenheim Altarpiece illustrates northern European preoccupation with Death and Disease, serving as a symbol of spiritual comfort and faith in salvation.
Explanation:
Matthias Grünewald's Isenheim Altarpiece underscores the northern European preoccupation with Death and Disease, particularly during troubled times preceding the Reformation. The altarpiece, created for the Isenheim hospital where patients suffered from ergotism (St. Anthony's Fire), serves as a paean to human suffering and faith in salvation. It exemplifies how art was used for spiritual comfort and to address religious needs in the context of illness and turmoil.
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