PLEASE HELPPPP

What is the relationship between mutation, the cell cycle, and cancer? Select all statements that apply.
A Mutated genes typically allow cells to respond to checkpoint proteins that halt the cell cycle, thus avoiding formation of tumors.
B. As a result of unregulated cell cycles, cells may become cancerous, meaning that the cells grow and divide uncontrollably.
С
Cancerous cells may form malignant tumors that invade and destroy surrounding healthy tissue.
D. Mutated, defective genes may cause cells to become unable to respond to signals that regulate the cell cycle.