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Sagot :
An osteoporosis drug targeting osteoblasts be expected to increase their activity.
Is osteoporosis associated with an increase in osteoblast activity?
Osteoporosis is thus induced not only by an increase in osteoclastic activity, but also by a physiologic decrease in osteoblastic activity. The ability of a bone to resist fracture is determined by its quality, which may be calculated using its mass. Teriparatide medication boosts bone-forming cell production, however discontinuing treatment may result in unpleasant side effects. The leading cause of bone fractures in the elderly is osteoporosis, which is caused by an imbalance between osteoclasts, bone-degrading cells, and osteoblasts, bone-building cells. Increased osteoblast proliferation increases Notch ligand Jagged1 levels in bone marrow and Notch intracellular domain (NICD) levels in Sca-1-positive/lineage-negative/c-Kit-positive (SLK) cells. Furthermore, PTH injection boosts stem cell quantity and engraftment potential.
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